Thyroid Binding Globuline

Hello Everyone,

Today we are going to talk about Thyroxine Binding Globuline.

When thyroid hormones are sevreted from your thyroid gland, they are bound to a carrier, a protein.  This protein is called “thyroxine- binding globuline” or TBG. 

So TGB is similar to a taxicab, and your thyroid hormones, T4 and T3, get into the cab, and they are transported to the liver, where they are converted. 

Then they jump back into the cab and they are transported to the rest of the body.  You have this little carrier goine anywhere and everywhere inside your body.  Trouble occurs when there are so many of these carrier proteins called TBG, these little taxicabs, that the normal amount of T4 and T3 that should be floating around isnt.  Its as if they get sucked up by this big sponge, by all of these little taxicabs or TBG.

So here is the thing…your TSH will look normal, your total T4 will look normal, your total T3 will look normal.  If those are the only markers that your doctor is checking then the problem will be completely missed.  This is why you need to run all of the thyroid tests, not just TSH, T3, and T4.  You need TSH, Resin T3 uptake, free thyroxine index, reverse T3, and the thyroid antibodies, in addition to the TBG, Free T3, Free T4, and Total T4.  If your TBG is too high, even though your TSH is normal, including T4 and T3, your doctor needs to check your T3 uptake.  It will show that, actually, the T3 uptake is low when the TBG’s are high.

Remember that the lab reference range of T3 uptake is extremely broad, where the optimal or functional range is much narrower.  Excess estrogen elevates TBG also.  Birth control pills contain estrogens.  Some face creams and cosmetics contain undisclosed estrogens.  And these estorgens can elevate in your body and they’re detoxified through the liver.  If you have poor liver function or inablitily to detoxify, this is yet another reason you could still have thyroid-type symptoms.  It is not necessarily a thyroid gland problem, but it is more of a liver problem.

It is important to realize that there may be many more causes of thyroid malfunction!  More than just, “My TSH is low.”  Again we want to do all of the testing and get to the root cause of what’s happening with the patient.  If the TBG is high, you could have low thyroid symptoms, but normal lab numbers, even though you are taking medications.

Don’t suffer anohter minute!  Call the office for a free consultation.

Have a great day!

Dr. Price


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